Description

(R)-Licarbazepine Acetate CAS NO 186694-45-1 is a high-purity, single-enantiomer pharmaceutical intermediate of significant importance in modern drug development. This compound serves as a critical chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the central nervous system therapeutic area. It is primarily required by pharmaceutical manufacturers and advanced research organizations engaged in the production and development of novel antiepileptic drugs and other neuroactive compounds.

Application

• Key Chiral Intermediate for the synthesis of Eslicarbazepine Acetate, a third-generation antiepileptic drug.
• Pharmaceutical Research & Development (R&D) for investigating new chemical entities targeting voltage-gated sodium channels.
• Active Pharmaceutical Ingredient (API) Manufacturing in cGMP-compliant facilities for final drug product formulation.
• Process Chemistry & Scale-Up studies to optimize synthetic routes for commercial production.
• Reference Standard for analytical method development and quality control in pharmaceutical laboratories.
• Academic & Institutional Research in neuropharmacology and medicinal chemistry.

Basic Information

Product Name	(R)-Licarbazepine Acetate
CAS No.	186694-45-1
Molecular Formula	C17H16N2O3
Molecular Weight	296.32 g/mol
Synonyms	(R)-10-Acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide; (R)-Eslicarbazepine Acetate Intermediate; (R)-10-Hydroxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide Acetate; (R)-Licarbazepine Acetate; (R)-BIA 2-195 Acetate; (R)-Enantiomer of Oxcarbazepine Acetate; (R)-10-O-Acetyl-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide
EINECS	Contact for details

Quality Control

Our (R)-Licarbazepine Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediates. We provide full traceability and detailed Certificates of Analysis (COA) that confirm identity, purity, and impurity profiles, supporting regulatory filings and cGMP compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Enantiomeric Excess)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.