Description

(S)-(-)-1,2,3,4-Tetrahydro-2,3-isoquinolinedicarboxylic acid is a high-purity chiral intermediate of significant importance in asymmetric synthesis. Its stereochemically defined structure makes it a valuable building block for the development of novel pharmaceuticals and fine chemicals. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for creating enantiomerically pure target molecules.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs) for central nervous system (CNS) drugs, enzyme inhibitors, and receptor modulators.
• Asymmetric Catalyst Ligand: Used in the preparation of chiral ligands for transition metal catalysis, enabling enantioselective transformations.
• Agrochemical Synthesis: Building block for developing novel, enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Process Research: Valuable reagent for methodological development in organic chemistry and scale-up process optimization.
• Fine Chemical Production: Intermediate for specialty chemicals requiring high optical purity, such as flavors, fragrances, and advanced polymers.

Basic Information

Product Name	(S)-(-)-1,2,3,4-Tetrahydro-2,3-isoquinolinedicarboxylic acid
CAS No.	186606-17-7
Molecular Formula	C11H11NO4
Molecular Weight	221.21 g/mol
Synonyms	(2S,3S)-1,2,3,4-Tetrahydro-2,3-isoquinolinedicarboxylic Acid; (S,S)-THIQDA; (2S,3S)-THIQ Dicarboxylic Acid; (S)-(-)-THIQ-2,3-dicarboxylic Acid; (2S,3S)-1,2,3,4-Tetrahydroisoquinoline-2,3-dicarboxylic Acid; (S,S)-1,2,3,4-Tetrahydroisoquinoline-2,3-dicarboxylic Acid; (S)-2,3-Dicarboxy-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our (S)-(-)-1,2,3,4-Tetrahydro-2,3-isoquinolinedicarboxylic acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chiral purity and chemical integrity, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, Chiral HPLC) are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.