Description

Benzene, 1-Iodo-2-Methoxy-4-Methyl- is a halogenated aromatic compound that serves as a versatile and valuable building block in advanced organic synthesis. Its unique structure, featuring iodine, methoxy, and methyl substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications such as cross-coupling reactions and the synthesis of functionalized aromatic systems.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the iodine atom facilitates further functionalization.
• Material Science Research: Employed in the creation of organic semiconductors, liquid crystals, and advanced polymers due to its electron-donating methoxy group and potential for cross-coupling.
• Cross-Coupling Reactions: Serves as an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings, enabling carbon-carbon bond formation.
• Ligand and Catalyst Development: Utilized as a starting material for synthesizing specialized ligands used in homogeneous catalysis.
• Chemical Research & Development: A fundamental reagent in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries.

Basic Information

Product Name	Benzene, 1-Iodo-2-Methoxy-4-Methyl-
CAS No.	186583-59-5
Molecular Formula	C8H9IO
Molecular Weight	248.06 g/mol
Synonyms	1-Iodo-2-methoxy-4-methylbenzene; 2-Iodo-5-methylanisole; 4-Methyl-2-iodoanisole; 2-Methoxy-4-methyl-1-iodobenzene; 5-Methyl-2-iodoanisole; 2-Iodo-5-methylmethoxybenzene; 1-Iodo-4-methyl-2-methoxybenzene; o-Iodo-p-methylanisole
EINECS	Contact for details

Quality Control

Our Benzene, 1-Iodo-2-Methoxy-4-Methyl- is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.