Description

(S)-n-tert-Butyl-1,2,3,4-Tetrahydroisoquinoline-3-Carboxamide Sulfate is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. Its value lies in its role as a key building block for the development of active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. This compound is essential for research institutions and manufacturers engaged in the production of complex, optically active drug candidates and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Asymmetric Synthesis: Used in the development of enantiomerically pure compounds for research and commercial pharmaceutical applications.
• Medicinal Chemistry Research: Serves as a key scaffold or precursor in drug discovery programs targeting neurological and other therapeutic areas.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals requiring specific stereochemistry.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Item	Detail
Product Name	(S)-n-tert-Butyl-1,2,3,4-Tetrahydroisoquinoline-3-Carboxamide Sulfate
CAS No.	186537-30-4
Molecular Formula	C14H20N2O • H2SO4 or C14H22N2O5S
Molecular Weight	330.40 g/mol
Synonyms	(S)-N-tert-Butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide sulfate; (S)-1,2,3,4-Tetrahydro-N-(1,1-dimethylethyl)-3-isoquinolinecarboxamide sulfate; (S)-TBQ Sulfate; (S)-N-tert-Butyl-TIQ-Carboxamide Sulfate; (S)-3-Carbamoyl-1,2,3,4-tetrahydroisoquinoline, N-tert-butyl-, sulfate; (S)-1,2,3,4-Tetrahydro-N-(tert-butyl)isoquinoline-3-carboxamide sulfate salt
EINECS	Contact for details

Quality Control

Our (S)-n-tert-Butyl-1,2,3,4-Tetrahydroisoquinoline-3-Carboxamide Sulfate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.