Description

Ethyl 5-[(3R)-4-(tert-Butoxycarbonylamino)-3-(Mesyloxy)Butyl]Thiophene-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a protected amino acid side chain and a reactive mesylate leaving group. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors and other small-molecule therapeutics. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in process chemistry, medicinal chemistry, and the production of novel drug candidates.

Application

• Key Intermediate in API Synthesis: Serves as a crucial building block for the construction of complex molecules in pharmaceutical manufacturing.
• Protease Inhibitor Development: Used in the research and production of protease inhibitor drugs, a major class of antivirals and other therapeutics.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and the exploration of new chemical entities in drug discovery programs.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and the pilot-to-commercial scale production of target molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.

Basic Information

Product Name	Ethyl 5-[(3R)-4-(tert-Butoxycarbonylamino)-3-(Mesyloxy)Butyl]Thiophene-2-Carboxylate
CAS No.	186521-39-1
Molecular Formula	C17H27NO6S2
Molecular Weight	405.53 g/mol
Synonyms	Ethyl 5-[(3R)-4-[(tert-Butoxycarbonyl)amino]-3-[(methylsulfonyl)oxy]butyl]-2-thiophenecarboxylate; (R)-Ethyl 5-(4-((tert-butoxycarbonyl)amino)-3-((methylsulfonyl)oxy)butyl)thiophene-2-carboxylate; Boc-Protected Amino Acid Thiophene Ester Mesylate; 186521-39-1; Thiophene-2-carboxylic acid, 5-[(3R)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-3-[(methylsulfonyl)oxy]butyl]-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 5-[(3R)-4-(tert-Butoxycarbonylamino)-3-(Mesyloxy)Butyl]Thiophene-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.