Description

Ethyl 5-[(3R)-4-(tert-Butoxycarbonylamino)-3-hydroxybutyl]thiophene-2-carboxylate is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound is specifically designed for the construction of complex active pharmaceutical ingredients (APIs), offering a critical stereogenic center and protected functional groups for precise molecular assembly. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and metabolic disorder targets.
• Protease Inhibitor Research: Serves as a precursor in the development of protease inhibitors, leveraging its specific stereochemistry and functional group array.
• Peptidomimetic Chemistry: Used in the design and synthesis of peptidomimetics, where the thiophene and protected amino alcohol motifs are valuable scaffolds.
• Asymmetric Synthesis: Employed in catalytic asymmetric reactions to introduce complex chiral fragments into larger molecular architectures.
• Process Chemistry & Scale-Up: Suitable for process research and development (PR&D) and pilot-scale manufacturing of clinical trial materials.
• Reference Standard: Can be supplied as a high-purity analytical reference standard for quality control and method development.

Basic Information

Product Name	Ethyl 5-[(3R)-4-(tert-Butoxycarbonylamino)-3-hydroxybutyl]thiophene-2-carboxylate
CAS No.	186521-38-0
Molecular Formula	C16H25NO5S
Molecular Weight	343.44 g/mol
Synonyms	Ethyl (R)-5-(4-((tert-butoxycarbonyl)amino)-3-hydroxybutyl)thiophene-2-carboxylate; (R)-Ethyl 5-(4-((tert-butoxycarbonyl)amino)-3-hydroxybutyl)thiophene-2-carboxylate; Boc-NH-(R)-CH(OH)CH2CH2CH2-2-Thiophene-COOEt; tert-Butyl ((3R)-3-hydroxy-4-(5-(ethoxycarbonyl)thiophen-2-yl)butyl)carbamate; 186521-38-0; Chiral Thiophene Intermediate
EINECS	Contact for details

Quality Control

Our Ethyl 5-[(3R)-4-(tert-Butoxycarbonylamino)-3-hydroxybutyl]thiophene-2-carboxylate is manufactured under controlled conditions to ensure consistent high quality and enantiomeric purity. Each batch is subjected to rigorous analytical testing, including chiral HPLC, NMR, and mass spectrometry, to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP guidelines for the production of pharmaceutical intermediates, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.