Description

6-Chloro-4-Fluoro-1H-Indole-2-Carboxylic Acid is a high-purity, multifunctional heterocyclic building block essential for advanced organic synthesis. This compound serves as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogenated indole scaffold enables precise molecular modifications. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for constructing complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potent drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used to develop new-generation herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Chemical Biology Probe: Serves as a scaffold for creating molecular probes to study enzyme function and biological pathways.
• Material Science: Potential building block for advanced organic electronic materials and functional polymers.
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development.

Basic Information

Product Name	6-Chloro-4-Fluoro-1H-Indole-2-Carboxylic Acid
CAS No.	186446-27-5
Molecular Formula	C9H5ClFNO2
Molecular Weight	213.59 g/mol
Synonyms	6-Chloro-4-fluoroindole-2-carboxylic acid; 4-Fluoro-6-chloro-1H-indole-2-carboxylic acid; 1H-Indole-2-carboxylic acid, 6-chloro-4-fluoro-; 6-Chloro-4-fluoro-2-indolecarboxylic acid; 186446-27-5; 6-Chloro-4-fluoro-1H-indole-2-carboxylate
EINECS	Contact for details

Quality Control

Our 6-Chloro-4-Fluoro-1H-Indole-2-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed HPLC/GC profiles, to support your regulatory and R&D requirements. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.