Description

5-Chloro-4-Fluoro-1H-Indole-2-Carboxylic Acid is a high-value halogenated indole derivative serving as a critical building block in advanced organic synthesis. Its molecular structure makes it an essential intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used as a core scaffold for developing new-generation herbicides, fungicides, and insecticides with improved efficacy.
• Chemical Research: Serves as a versatile building block in medicinal chemistry and process research for structure-activity relationship (SAR) studies.
• Material Science: Potential intermediate for synthesizing functional dyes, pigments, and advanced organic electronic materials.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	5-Chloro-4-Fluoro-1H-Indole-2-Carboxylic Acid
CAS No.	186446-26-4
Molecular Formula	C9H5ClFNO2
Molecular Weight	213.59 g/mol
Synonyms	5-Chloro-4-fluoroindole-2-carboxylic acid; 4-Fluoro-5-chloro-1H-indole-2-carboxylic acid; 1H-Indole-2-carboxylic acid, 5-chloro-4-fluoro-; 186446-26-4; 5-Chloro-4-fluoro-2-indolecarboxylic acid; 5-Chloro-4-fluoroindole-2-carboxylate
EINECS	Contact for details

Quality Control

Our 5-Chloro-4-Fluoro-1H-Indole-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements of our global clientele. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.