Description

7-Bromo-6-Nitro-n-tert-Butoxycarbonyl-1,2,3,4-Tetrahydroisoquinoline is a high-purity, advanced pharmaceutical intermediate characterized by its specific bromo-nitro substitution pattern on the tetrahydroisoquinoline scaffold. This compound is critical for medicinal chemistry research and development, serving as a key building block for the synthesis of complex bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing novel therapeutic agents, particularly in the areas of central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel drug candidates, especially those targeting specific receptor sites.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize the biological activity of tetrahydroisoquinoline-based compounds.
• API Development: Serves as a building block in the development of Active Pharmaceutical Ingredients (APIs) with potential neurological or oncological applications.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis: Used by contract research and manufacturing organizations (CROs/CMOs) for client-specific synthetic projects requiring this specialized heterocycle.
• Academic Research: A valuable reagent for universities and research institutes conducting studies in organic synthesis methodology and heterocyclic chemistry.

Basic Information

Product Name	7-Bromo-6-Nitro-n-tert-Butoxycarbonyl-1,2,3,4-Tetrahydroisoquinoline
CAS No.	186390-63-6
Molecular Formula	C₁₄H₁₇BrN₂O₄
Molecular Weight	357.20 g/mol
Synonyms	7-Bromo-6-nitro-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 2-(tert-Butoxycarbonyl)-7-bromo-6-nitro-1,2,3,4-tetrahydroisoquinoline; 7-Bromo-6-nitro-2-N-Boc-1,2,3,4-tetrahydroisoquinoline; Boc-7-Bromo-6-nitro-THIQ; tert-Butyl 7-bromo-6-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylate; 186390-63-6; 7-Br-6-NO2-N-Boc-THIQ
EINECS	Contact for details

Quality Control

Our 7-Bromo-6-Nitro-n-tert-Butoxycarbonyl-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards expected for pharmaceutical R&D, ensuring reliable and reproducible results for your synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.