Description

[1,1'-Biphenyl]-2-Carboxamide, n-[1,2,3,4-Tetrahydro-2-(1H-Imidazol-2-Ylmethyl)-6-Isoquinolinyl]-4'-(Trifluoromethyl)- is a sophisticated, high-purity organic compound designed for advanced research and development. This molecule is of significant interest due to its complex heterocyclic structure, which incorporates key pharmacophores like the imidazole and tetrahydroisoquinoline moieties. It serves as a critical pharmaceutical intermediate or reference standard for medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used as a core scaffold or precursor for structure-activity relationship (SAR) studies and lead optimization.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in API manufacturing.
• Biochemical Research: Potential tool compound for investigating enzyme inhibition or receptor binding assays relevant to disease pathways.
• Process Development: Employed in scaling up synthetic routes for preclinical and clinical trial material production.
• Academic Research: Used in university and institutional labs for cutting-edge organic synthesis and pharmacology studies.

Basic Information

Product Name	[1,1'-Biphenyl]-2-Carboxamide, n-[1,2,3,4-Tetrahydro-2-(1H-Imidazol-2-Ylmethyl)-6-Isoquinolinyl]-4'-(Trifluoromethyl)-
CAS No.	186390-35-2
Molecular Formula	C27H25F3N4O
Molecular Weight	478.51 g/mol
Synonyms	N-[1,2,3,4-Tetrahydro-2-(1H-imidazol-2-ylmethyl)-6-isoquinolinyl]-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamide; 4'-(Trifluoromethyl)-N-[1,2,3,4-tetrahydro-2-(1H-imidazol-2-ylmethyl)-6-isoquinolinyl][1,1'-biphenyl]-2-carboxamide; Biphenyl-2-carboxamide derivative; Tetrahydroisoquinoline-imidazole carboxamide; TRK-530 (research code); CNS-active intermediate; Imidazole-isoquinoline hybrid compound.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch is characterized and purified to meet exacting standards for research and development use. Comprehensive analytical testing, including HPLC, NMR, and MS, ensures identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.