Description

Boc-L-Octahydroindole-2-Carboxylic Acid is a protected, non-proteinogenic amino acid derivative of significant importance in advanced organic synthesis. This compound serves as a critical chiral building block for the construction of complex peptide mimetics and constrained peptidomimetics, enabling the development of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of peptide-based therapeutics, protease inhibitors, and other drug discovery programs.

Application

• Peptidomimetic Drug Discovery: A key intermediate for synthesizing conformationally restricted peptide analogs to enhance metabolic stability and receptor selectivity.
• Protease Inhibitor Synthesis: Used in the construction of active site-directed inhibitors for various proteolytic enzymes.
• Combinatorial Chemistry Libraries: Serves as a valuable scaffold for generating diverse libraries of small molecules for high-throughput screening.
• Solid-Phase Peptide Synthesis (SPPS): Employed as a Boc-protected amino acid for the sequential assembly of specialized peptides.
• Bioconjugation and Linker Chemistry: Utilized in the design of drug-linker systems for antibody-drug conjugates (ADCs) and other targeted therapies.
• Academic and Industrial Research: Fundamental building block in medicinal chemistry research for studying structure-activity relationships (SAR).

Basic Information

Product Name	Boc-L-Octahydroindole-2-Carboxylic Acid
CAS No.	186096-30-0
Molecular Formula	C14H23NO4
Molecular Weight	269.34 g/mol
Synonyms	(2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]octahydro-1H-indole-2-carboxylic acid; (2S)-1-(tert-Butoxycarbonyl)octahydroindole-2-carboxylic acid; Boc-(S)-octahydroindole-2-carboxylic acid; Boc-L-Oic-OH; (S)-1-Boc-2-carboxyperhydroindole; L-1-Boc-2-carboxyperhydroindole; tert-Butoxycarbonyl-L-octahydroindole-2-carboxylic acid; BOC-L-OCTAHYDROINDOLE-2-CARBOXYLIC ACID
EINECS	Contact for details

Quality Control

Our Boc-L-Octahydroindole-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, meeting the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) providing detailed specifications for identity, purity (typically by HPLC), and chiral purity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.