Description

(1R,3Ar,7Ar)-1-((S)-1-Hydroxypropan-2-Yl)-7A-Methyloctahydro-1H-Inden-4-Ol is a high-purity, stereochemically defined synthetic intermediate of significant importance in advanced pharmaceutical research and development. Its complex, polycyclic structure makes it a valuable chiral building block for the synthesis of novel therapeutic agents, particularly in the fields of endocrinology and metabolic disease. This compound is essential for R&D chemists and process development scientists working on complex molecule synthesis, where precise stereochemical control is paramount. The CAS number for this compound is 185997-26-6.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of complex drug candidates, particularly steroids and terpenoid-based therapeutics.
• Steroid Analog Research: Used as a foundational scaffold for developing novel steroid receptor modulators with potential applications in hormone-related therapies.
• Process Chemistry Development: Employed in route scouting and optimization for the commercial-scale production of high-value active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Acts as a starting material or intermediate in catalytic asymmetric transformations to construct molecules with high enantiomeric purity.
• Medicinal Chemistry Libraries: Utilized to generate focused libraries of compounds for high-throughput screening (HTS) against biological targets.
• Reference Standard: Supplied as an analytical standard for method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	(1R,3Ar,7Ar)-1-((S)-1-Hydroxypropan-2-Yl)-7A-Methyloctahydro-1H-Inden-4-Ol
CAS No.	185997-26-6
Molecular Formula	C14H26O2
Molecular Weight	226.36 g/mol
Synonyms	7a-Methyl-1-[(1S)-1-hydroxypropan-2-yl]octahydro-1H-inden-4-ol (stereoisomer); (1R,3aR,7aS)-1-[(1S)-1-Hydroxypropan-2-yl]-7a-methyloctahydro-1H-inden-4-ol; 185997-26-6; (1R,3aR,7aS)-rel-1-[(1S)-1-Hydroxy-2-propanyl]-7a-methyloctahydro-1H-inden-4-ol; A key intermediate for Galeterone/TOK-001 synthesis; Steroidal indanol derivative.
EINECS	Contact for details

Quality Control

Every batch of (1R,3Ar,7Ar)-1-((S)-1-Hydroxypropan-2-Yl)-7A-Methyloctahydro-1H-Inden-4-Ol is manufactured under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for advanced pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.