Description

1-Methyl-2-Pyrrolidinone-D9 is a deuterated analog of the versatile polar aprotic solvent N-Methyl-2-pyrrolidone (NMP), where nine hydrogen atoms are replaced with deuterium. This isotopic labeling makes it an essential tool for advanced analytical and research applications where precise molecular tracking and spectroscopic clarity are paramount. It is primarily required by pharmaceutical researchers, NMR spectroscopists, and analytical chemists working in drug metabolism studies, reaction mechanism elucidation, and as an internal standard.

Application

• NMR Spectroscopy: Used as a deuterated solvent for nuclear magnetic resonance (NMR) analysis, providing a non-interfering signal background.
• Pharmaceutical Research: Serves as a critical reagent in drug discovery and development, particularly in pharmacokinetic and metabolic studies using mass spectrometry.
• Internal Standard: Acts as a high-purity internal standard in quantitative analytical methods like GC-MS and LC-MS for accurate calibration.
• Chemical Synthesis: Employed in specialized synthetic pathways where deuterium labeling is required for mechanistic studies or to produce deuterated target molecules.
• Material Science Research: Used in the study of polymer chemistry and other material systems where solvent isotope effects are investigated.

Basic Information

Product Name	1-Methyl-2-Pyrrolidinone-D9
CAS No.	185964-60-7
Molecular Formula	C5D9NO
Molecular Weight	114.19 g/mol
Synonyms	N-Methyl-2-pyrrolidinone-D9; NMP-D9; 1-Methyl-2-pyrrolidone-D9; N-Methyl-2-pyrrolidone-D9; Deuterated NMP; Perdeuterated N-Methyl-2-pyrrolidinone; [D9]-N-Methyl-2-pyrrolidinone; 2-Pyrrolidinone, 1-methyl-, D9
EINECS	Contact for details

Quality Control

Our 1-Methyl-2-Pyrrolidinone-D9 is produced and handled under stringent conditions to ensure exceptional isotopic purity and chemical integrity, meeting the exacting requirements of analytical and research laboratories. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (D-content), chemical purity, and NMR solvent suitability. We adhere to rigorous internal quality standards to guarantee batch-to-batch consistency and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure containers are sealed properly after use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Isotopic Purity (D-content)	≥ 99.0 atom % D
Chemical Purity (GC)	≥ 99.5%
Water Content (KF)	≤ 0.1%
NMR Solvent Suitability	Passes test

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.