Description

6,7,8-Indolizinetriol, 1-(1,1-Dimethylethyl)dimethylsilyloxyoctahydro-, 1S-(1.Alpha.,6.Beta.,7.Alpha.,8.Beta.,8A.Beta.)- is a complex, stereochemically defined indolizine derivative, primarily utilized as a key chiral intermediate in advanced organic synthesis. Its value lies in its intricate polyhydroxylated structure, which serves as a sophisticated building block for constructing biologically active molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical sectors, particularly for the development of novel therapeutics and complex natural product analogs.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially those targeting complex biological pathways.
• Organic Synthesis Building Block: Used in multi-step synthetic routes to construct complex molecular architectures found in natural products and specialty chemicals.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization processes due to its defined stereochemistry and functional groups.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric reactions to produce enantiomerically pure compounds.
• Biochemical Research: Potential use as a precursor or analog in the study of enzyme inhibitors or other bioactive molecules.
• Fine Chemical Production: Integral to the manufacture of high-value, low-volume specialty chemicals with specific stereochemical requirements.

Basic Information

Item	Details
Product Name	6,7,8-Indolizinetriol, 1-(1,1-Dimethylethyl)dimethylsilyloxyoctahydro-, 1S-(1.Alpha.,6.Beta.,7.Alpha.,8.Beta.,8A.Beta.)-
CAS No.	185899-44-9
Molecular Formula	C16H32O4Si
Molecular Weight	316.51 g/mol
Synonyms	(1S,6R,7R,8R,8aR)-1-[(tert-Butyldimethylsilyl)oxy]octahydro-6,7,8-indolizinetriol; 1-O-(tert-Butyldimethylsilyl)-1-deoxynojirimycin derivative; TBDMS-protected indolizinetriol; 1S-(1α,6β,7α,8β,8aβ)-Octahydro-6,7,8-trihydroxy-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]indolizine; 1-Deoxynojirimycin TBDMS ether; DNJ TBDMS derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and cGMP manufacturing needs with appropriate documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.