Description

Indinavir-D-6 CAS NO 185897-02-3 is a stable isotope-labeled analog of the antiretroviral protease inhibitor Indinavir, where six hydrogen atoms are replaced by deuterium. This compound is a critical tool for quantitative bioanalytical research, providing an essential internal standard for mass spectrometry to ensure accurate pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced drug development and metabolism research for HIV therapeutics.

Application

• Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of Indinavir in biological matrices (plasma, serum, tissues).
• Essential for conducting pharmacokinetic (PK) and bioavailability studies during drug development and regulatory submissions.
• Facilitates drug metabolism and disposition (DMPK) research, helping to elucidate metabolic pathways and stability.
• Supports clinical trial analysis, ensuring data integrity and compliance with Good Laboratory Practice (GLP) standards.
• Enables forensic and anti-doping analysis where accurate measurement of drug concentrations is required.
• Applied in method development and validation for analytical laboratories to achieve high specificity and sensitivity.

Basic Information

Product Name	Indinavir-D-6
CAS No.	185897-02-3
Molecular Formula	C36H41D6N5O4
Molecular Weight	~ 615.8 g/mol
Synonyms	Deuterated Indinavir (d6); [2H6]-Indinavir; Indinavir-d6; MK-639-d6; L-735,524-d6; (2S)-1-[(2S,4S)-4-Benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide-d6; Crixivan-d6
EINECS	Contact for details

Quality Control

Every batch of Indinavir-D-6 is manufactured and analyzed under strict quality systems to ensure the highest standards of isotopic purity and chemical identity, which are paramount for reliable analytical results. We provide comprehensive Certificates of Analysis (COA) detailing specifications for isotopic enrichment, chemical purity, and absence of interfering impurities. Our quality commitment aligns with the needs of GLP-compliant and research-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.