Description

Cyclopropaneacetic Acid, 2-Amino-2-Carboxy-, (1S-Cis)- (9Ci) is a high-purity, non-proteinogenic amino acid derivative featuring a unique cyclopropane ring structure. This compound is a critical chiral building block in advanced pharmaceutical synthesis, enabling the development of novel therapeutic agents with enhanced biological activity and metabolic stability. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of peptide-based drugs, enzyme inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in peptide mimetics and protease inhibitors.
• Peptide Chemistry: Used to incorporate the constrained cyclopropane moiety into peptide backbones to modulate conformation, stability, and receptor binding affinity.
• Medicinal Chemistry Research: Serves as a valuable scaffold in drug discovery programs for creating compound libraries and probing structure-activity relationships (SAR).
• Biochemical Tool: Potential application as an enzyme substrate or inhibitor in biochemical assays and mechanistic studies.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in stereoselective synthesis due to its defined (1S-cis) configuration.

Basic Information

Product Name	Cyclopropaneacetic Acid, 2-Amino-2-Carboxy-, (1S-Cis)- (9Ci)
CAS No.	185527-67-7
Molecular Formula	C6H9NO4
Molecular Weight	159.14 g/mol
Synonyms	(1S,2S)-2-Aminocyclopropane-1-carboxylic acid; (1S-cis)-2-Aminocyclopropanecarboxylic acid; cis-2-Aminocyclopropanecarboxylic acid; ACC; cis-ACPC; (1S,2S)-ACPC; 2-Amino-1-cyclopropanecarboxylic acid (cis-); L-cis-2-Aminocyclopropanecarboxylic acid
EINECS	Contact for details

Quality Control

Our Cyclopropaneacetic Acid, 2-Amino-2-Carboxy-, (1S-Cis)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) providing full specifications, including assay, enantiomeric excess, and impurity profiles, is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.