Description

Enrofloxacin n-Oxide is a significant metabolite and degradation product of the widely used veterinary fluoroquinolone antibiotic, enrofloxacin. This compound is crucial for analytical and research purposes, particularly in the fields of veterinary pharmacology and food safety. It serves as a primary reference standard for the accurate detection, quantification, and study of enrofloxacin residues in animal-derived products and environmental samples.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for quality control and method validation in analytical laboratories.
• Veterinary Drug Residue Analysis: Essential for developing and calibrating HPLC, LC-MS/MS, and other analytical methods to monitor enrofloxacin and its metabolites in meat, milk, eggs, and honey.
• Metabolism and Pharmacokinetic Studies: Used in research to understand the metabolic pathways, bioavailability, and excretion profiles of enrofloxacin in food-producing animals.
• Environmental Monitoring: Acts as a marker compound in studies assessing the environmental impact and degradation of fluoroquinolone antibiotics in water and soil.
• Regulatory Compliance Testing: Supports testing to ensure compliance with maximum residue limits (MRLs) set by agencies like the FDA, EMA, and other global food safety authorities.
• Impurity Profiling: Used in the pharmaceutical industry to identify and quantify this specific impurity in enrofloxacin active pharmaceutical ingredient (API) and formulated products.

Basic Information

Product Name	Enrofloxacin n-Oxide
CAS No.	185460-67-7
Molecular Formula	C19H22FN3O4
Molecular Weight	375.40 g/mol
Synonyms	1-Cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid N-Oxide; Enrofloxacin N-Oxide; Bay Vp 2674 N-Oxide; Enrofloxacin Impurity F (EP); Enrofloxacin N-Oxide (EP Impurity F); 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid, N-Oxide; Enrofloxacin Related Compound F
EINECS	Contact for details

Quality Control

Our Enrofloxacin n-Oxide is manufactured and handled under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for reference materials. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every product. We can support compliance with various pharmacopoeial standards, including EP (Enrofloxacin Impurity F) and USP, upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.