Description

8-Benzenesulfonyl-6-Hydroxy-2,3-Dihydro-1H-Indolizin-5-One is a high-purity, functionalized indolizinone derivative of significant interest in advanced organic synthesis. This compound matters as a versatile and critical synthetic intermediate, enabling the construction of complex heterocyclic scaffolds with potential biological activity. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, or infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or insecticides, leveraging its heterocyclic core for bioactivity.
• Chemical Biology Probe: Acts as a precursor for creating molecular probes to study enzyme function or protein-protein interactions within biological systems.
• Material Science Precursor: Potential starting material for the synthesis of organic electronic materials or specialty dyes due to its conjugated structure.
• Academic & Contract Research: Essential for methodology development and exploratory chemistry in university laboratories and contract research organizations (CROs).
• Custom Synthesis & Scale-Up: A critical intermediate for custom manufacturing and process optimization services, supporting projects from milligram to kilogram scale.

Basic Information

Product Name	8-Benzenesulfonyl-6-Hydroxy-2,3-Dihydro-1H-Indolizin-5-One
CAS No.	185198-43-0
Molecular Formula	C₁₄H₁₁NO₄S
Molecular Weight	289.31 g/mol
Synonyms	8-(Phenylsulfonyl)-6-hydroxy-2,3-dihydro-1H-indolizin-5-one; 6-Hydroxy-8-(phenylsulfonyl)-2,3-dihydro-1H-indolizin-5-one; 5(1H)-Indolizinone, 2,3-dihydro-6-hydroxy-8-(phenylsulfonyl)-; 185198-43-0; 8-Benzenesulfonyl-6-hydroxy-2,3-dihydroindolizin-5-one
EINECS	Contact for details

Quality Control

Our 8-Benzenesulfonyl-6-Hydroxy-2,3-Dihydro-1H-Indolizin-5-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with complete batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.