Description

Coumarin-5,6,7,8-D4 is a deuterium-labeled analog of the naturally occurring coumarin derivative, specifically isotopically labeled at the 5, 6, 7, and 8 positions. This compound is an essential stable isotope-labeled internal standard for precise quantitative analysis in advanced mass spectrometry applications. It is primarily used by researchers and quality control laboratories in the pharmaceutical, analytical chemistry, and life science sectors.

Application

• Internal Standard for LC-MS/MS: Used for the accurate quantification of coumarin and its metabolites in pharmacokinetic and bioanalytical studies.
• Metabolic Pathway Tracing: Employed in drug metabolism and disposition (DMPK) research to elucidate metabolic pathways.
• Pharmaceutical Impurity Profiling: Serves as a reference standard in the analysis of drug substances and products for impurity identification and control.
• Food and Flavor Analysis: Applied in the detection and quantification of coumarin in foodstuffs, beverages, and flavorings for regulatory compliance.
• Environmental Monitoring: Utilized as a tracer in environmental fate studies of coumarin-based compounds.
• Synthetic Chemistry: Acts as a labeled building block for the synthesis of more complex deuterated molecules for research.

Basic Information

Item	Detail
Product Name	Coumarin-5,6,7,8-D4
CAS No.	185056-83-1
Molecular Formula	C₉D₄H₄O₂
Molecular Weight	150.17 g/mol
Synonyms	2H-1-Benzopyran-2-one-5,6,7,8-d4; Coumarin-d4; 1,2-Benzopyrone-d4; 5,6,7,8-Tetradeuteriocoumarin; Coumarin (5,6,7,8-D4); Benzo-2-pyrone-d4; cis-o-Coumaric acid lactone-d4; Tonka bean camphor-d4
EINECS	Contact for details

Quality Control

Every batch of Coumarin-5,6,7,8-D4 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity to meet the exacting demands of analytical reference standards. Comprehensive testing includes assay by HPLC, isotopic enrichment by NMR or MS, and identification by FTIR. A Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.