Description

2-Fluoro-3-(trifluoromethyl)benzyl bromide is a versatile and highly reactive benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic combination of fluorine and bromine substituents, which enables precise molecular modifications essential for developing high-performance materials and active compounds. This intermediate is particularly vital for R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to introduce functional complexity into target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules requiring fluorinated aromatic systems to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides, where the trifluoromethyl and fluorine groups enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis, facilitating challenging cross-coupling and functionalization reactions.
• Material Science Research: Intermediate for creating fluorinated polymers, liquid crystals, and organic electronic materials, contributing to unique optical and electronic properties.
• Custom Chemical Synthesis: Employed in contract research and manufacturing (CRO/CMO) for the custom synthesis of complex, fluorinated organic compounds for various industrial applications.

Basic Information

Product Name	2-Fluoro-3-(trifluoromethyl)benzyl bromide
CAS No.	184970-25-0
Molecular Formula	C8H5BrF4
Molecular Weight	257.03 g/mol
Synonyms	1-(Bromomethyl)-2-fluoro-3-(trifluoromethyl)benzene; α-Bromo-2-fluoro-α,α,α-trifluoro-m-xylene; (2-Fluoro-3-(trifluoromethyl)phenyl)methyl bromide; 2-Fluoro-α-(bromomethyl)-3-(trifluoromethyl)toluene; 3-(Bromomethyl)-2-fluorobenzotrifluoride; 2-Fluoro-3-trifluoromethylbenzyl bromide
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-3-(trifluoromethyl)benzyl bromide is produced and tested under a strict quality management system. We employ advanced analytical techniques including GC, HPLC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.