Description

(S)-4-Mercapto-2-Pyrrolidinone CAS NO 184759-58-8 is a high-purity, chiral building block featuring a reactive thiol group and a lactam ring. This compound matters as a critical intermediate for the synthesis of complex pharmaceutical molecules, particularly in the development of protease inhibitors and other bioactive compounds. It is primarily needed by research institutions and manufacturers in the pharmaceutical and biotechnology industries for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of protease inhibitors, such as HIV-1 protease inhibitors and renin inhibitors.
• Peptidomimetics Research: Used to incorporate a constrained, sulfur-containing proline analogue into peptide backbones to modulate biological activity and stability.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in stereoselective chemical reactions.
• Bioconjugation Chemistry: The free thiol group enables site-specific modification of proteins, peptides, and other biomolecules.
• Ligand Development: Utilized in the creation of novel ligands for catalysis or molecular recognition.
• Chemical Biology Probes: Building block for developing activity-based probes to study enzyme function.

Basic Information

Product Name	(S)-4-Mercapto-2-Pyrrolidinone
CAS No.	184759-58-8
Molecular Formula	C4H7NOS
Molecular Weight	117.17 g/mol
Synonyms	(S)-4-Mercaptopyrrolidin-2-one; (4S)-4-Sulfanyl-2-pyrrolidinone; (S)-4-Mercapto-2-pyrrolidone; (S)-4-Thiol-2-pyrrolidinone; L-4-Mercapto-2-pyrrolidinone; (S)-4-Mercaptobutyrolactam; (S)-4-Mercapto-α-pyrrolidinone; (S)-4-Mercapto-dihydro-2(3H)-pyrrolidinone
EINECS	Contact for details

Quality Control

Our (S)-4-Mercapto-2-Pyrrolidinone is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with exacting standards for research and pharmaceutical use. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, separate from oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.