Description

2,3,4-Tris-o-(Phenylmethyl)-α-D-Glucopyranuronic Acid Phenylmethyl Ester 1-(2,2,2-Trichloroethanimidate) is a sophisticated glycosyl donor intermediate, specifically a trichloroacetimidate derivative, which is pivotal for stereoselective glycosylation reactions in complex carbohydrate synthesis. Its value lies in providing high reactivity and excellent anomeric control, enabling the efficient construction of challenging oligosaccharide and glycoconjugate structures. This compound is essential for researchers and process chemists in pharmaceutical development, particularly for creating novel glycotherapeutics, vaccines, and diagnostic agents.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of complex carbohydrate-based active pharmaceutical ingredients (APIs) and glycoconjugates.
• Glycobiology Research: Used as a key reagent in academic and industrial labs for studying glycosylation pathways and synthesizing defined oligosaccharides.
• Vaccine Development: Enables the construction of synthetic carbohydrate antigens for conjugate vaccine candidates against bacterial pathogens.
• Glycopeptide Synthesis: Facilitates the site-specific glycosylation of peptides and proteins to create homogeneous glycopeptide analogs.
• Process Chemistry: Employed in scale-up syntheses for the production of carbohydrate drugs and advanced intermediates under controlled conditions.
• Diagnostic Reagent Manufacturing: Serves as a precursor for labeled sugars used in diagnostic assays and imaging probes.

Basic Information

Product Name	2,3,4-Tris-o-(Phenylmethyl)-α-D-Glucopyranuronic Acid Phenylmethyl Ester 1-(2,2,2-Trichloroethanimidate)
CAS No.	184698-69-9
Molecular Formula	C36H34Cl3NO7
Molecular Weight	699.02 g/mol
Synonyms	1-O-(2,2,2-Trichloroethanimidoyl)-2,3,4-tri-O-benzyl-α-D-glucopyranuronic acid benzyl ester; 2,3,4-Tri-O-benzyl-α-D-glucopyranosyluronic acid benzyl ester trichloroacetimidate; Benzyl 2,3,4-tri-O-benzyl-1-O-(2,2,2-trichloroethanimidoyl)-α-D-glucopyranuronate; Glucuronic Acid Trichloroacetimidate Derivative; Glycosyl Donor Trichloroacetimidate; CAS 184698-69-9
EINECS	Contact for details

Quality Control

Every batch of this high-purity synthetic intermediate is produced under strict quality management systems. We ensure compliance with ICH guidelines for impurities and utilize advanced analytical techniques including HPLC, NMR, and MS for identity confirmation and purity verification. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and physical characteristics is provided with each shipment to guarantee traceability and meet the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. For long-term storage, consider storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.