Description

1,4-Benzenediamine, 2-Nitro-, Labeled With Carbon-14 (9Ci) is a high-specific-activity, isotopically labeled derivative of 2-nitro-p-phenylenediamine, where a carbon atom is replaced with the radioactive isotope carbon-14. This compound is essential for advanced tracer studies, metabolic pathway analysis, and environmental fate research, providing critical data on chemical behavior and degradation. It is primarily utilized by pharmaceutical R&D laboratories, agrochemical developers, and environmental testing facilities requiring precise tracking of molecular transformations.

Application

• Metabolic and Pharmacokinetic Studies: Used as a radiolabeled tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of related chemical entities in drug development.
• Environmental Degradation Research: Tracks the breakdown pathways and persistence of nitro-aromatic compounds in soil and water systems.
• Mechanistic Biochemistry Research: Elucidates enzymatic reaction mechanisms involving aromatic amine intermediates.
• Dye and Polymer Chemistry Studies: Investigates the synthesis and stability mechanisms of azo dyes and polyurethane precursors.
• Toxicology and Safety Assessment: Aids in studying the bioactivation and covalent binding of nitro-aromatic amines to macromolecules.
• Reference Standard for Analytical Method Development: Serves as a critical standard for calibrating HPLC, LC-MS, and radio-TLC methods in analytical laboratories.

Basic Information

Item	Detail
Product Name	1,4-Benzenediamine, 2-Nitro-, Labeled With Carbon-14 (9Ci)
CAS No.	183870-67-9
Molecular Formula	C6H7N3*O2 (*denotes 14C label)
Molecular Weight	~153.14 g/mol (exact value depends on labeling position)
Synonyms	2-Nitro-p-phenylenediamine-14C; 4-Amino-2-nitroaniline-14C; 1,4-Diamino-2-nitrobenzene-14C; 2-Nitro-1,4-benzenediamine-14C; [14C]-2-Nitro-PPD; Radiolabeled 2-Nitro-1,4-diaminobenzene; Carbon-14 Labeled 2-Nitro-p-Phenylenediamine
EINECS	Contact for details

Quality Control

Every batch of this radiolabeled compound is produced and analyzed under strict cGMP-like conditions to ensure identity, purity, and specific activity. Quality is verified by HPLC with radiometric detection, radio-TLC, and UV-Vis spectroscopy. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing the radiochemical purity (typically >97%), chemical purity, specific activity (9 Ci/mmol), and solvent composition. Our quality system is designed to meet the stringent requirements of GLP and GMP-compliant research environments.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C in a dedicated, appropriately shielded freezer for radioactive materials. The product is light-sensitive (store away from light). Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation. Users must handle and dispose of this material in accordance with all applicable local, national, and international radiation safety regulations.

Specification

Item	Specification
Appearance	Solid (Color may vary)
Identification (IR)	Conforms to structure
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Specific Activity	9 Ci/mmol
Solvent	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.