Description

trans-3-[(tert-Butyldimethylsilyl)Oxy]Cyclopentan-1-Ol is a high-value, protected chiral intermediate of significant importance in advanced organic synthesis. Its core value lies in providing a versatile, stereodefined building block for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for chemists and manufacturers in the fine chemical and pharmaceutical industries who require high-purity intermediates for the synthesis of active pharmaceutical ingredients (APIs) and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Asymmetric Synthesis: Serves as a crucial starting material or intermediate in stereoselective reactions to introduce the cyclopentanol moiety with defined stereochemistry.
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) group protects the alcohol functionality, allowing for selective reactions at other sites on the molecule during complex synthetic sequences.
• Process Chemistry & Scale-up: Used in the development and optimization of scalable manufacturing routes for target molecules in kilo-lab and pilot plant settings.
• Academic & Contract Research: Employed in research institutions and CROs (Contract Research Organizations) for medicinal chemistry programs and methodological studies.
• Fine Chemical Production: Integral to the production of specialized fine chemicals, flavors, and fragrances that require high stereochemical purity.

Basic Information

Product Name	trans-3-[(tert-Butyldimethylsilyl)Oxy]Cyclopentan-1-Ol
CAS No.	183795-20-2
Molecular Formula	C11H24O2Si
Molecular Weight	216.40 g/mol
Synonyms	trans-3-[(tert-Butyldimethylsilyl)oxy]cyclopentanol; (1R,3S)-3-[(tert-Butyldimethylsilyl)oxy]cyclopentan-1-ol; (1S,3R)-3-[(tert-Butyldimethylsilyl)oxy]cyclopentan-1-ol; 3-[(Tert-butyldimethylsilyl)oxy]cyclopentanol (trans); trans-3-(TBDMS-oxy)cyclopentanol; TBDMS-protected trans-3-hydroxycyclopentanol; Cyclopentanol, 3-[(1,1-dimethylethyl)dimethylsilyl]oxy]-, trans-
EINECS	Contact for details

Quality Control

Our trans-3-[(tert-Butyldimethylsilyl)Oxy]Cyclopentan-1-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. This compound may be sensitive to fluoride ions and strong alkali; store separately from such materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.