Description

Catramilast is a potent and selective phosphodiesterase 4 (PDE4) inhibitor with significant therapeutic potential. This compound matters for its targeted mechanism of action, which modulates inflammatory pathways, making it a valuable candidate for pharmaceutical research and development. It is primarily needed by pharmaceutical companies and research institutions focused on developing novel treatments for inflammatory and autoimmune diseases, such as chronic obstructive pulmonary disease (COPD), psoriasis, and atopic dermatitis.

Application

• Pharmaceutical intermediate for the synthesis of novel anti-inflammatory drug candidates.
• Key reference standard in analytical method development and validation for PDE4 inhibitor assays.
• Active pharmaceutical ingredient (API) in preclinical and clinical research for respiratory diseases.
• Biochemical tool for studying PDE4 enzyme kinetics and cellular signaling pathways in immunology research.
• Potential therapeutic agent for dermatological conditions like psoriasis and atopic dermatitis.
• Investigational compound for neurological research targeting neuroinflammation.

Basic Information

Product Name	Catramilast
CAS No.	183659-72-5
Molecular Formula	C20H21N3O4S
Molecular Weight	399.46 g/mol
Synonyms	CC-10004; CDC-801; 4-[(3,4-Dimethoxyphenyl)methyl]-2(1H)-quinazolinone; 4-[(3,4-Dimethoxybenzyl)amino]-2(1H)-quinazolinone; 4-(3,4-Dimethoxybenzylamino)quinazolin-2(1H)-one; PDE4 Inhibitor CC-10004; Apremilast Intermediate
EINECS	Contact for details

Quality Control

Our Catramilast is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing all specifications and test results. We adhere to cGMP standards where applicable to support our clients' regulatory requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.