Description

L-Homocystine-D8 is a stable isotope-labeled analog of the amino acid derivative homocystine, where eight hydrogen atoms are replaced by deuterium. This high-purity labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reproducibility in analytical measurements. It is a critical reagent for researchers and quality control laboratories in pharmaceutical development, clinical diagnostics, and metabolic research who require precise quantification of homocystine and related metabolites.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a crucial internal standard for the accurate quantification of L-homocystine and its related metabolites in complex biological matrices.
• Pharmaceutical R&D and Bioanalysis: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies to track drug metabolism and understand biochemical pathways involving sulfur-containing amino acids.
• Clinical Diagnostics and Research: Enables precise measurement of homocystine levels in plasma, serum, or urine for studies related to cardiovascular health, homocystinuria, and other metabolic disorders.
• Metabolic Pathway Tracing: Facilitates advanced research in sulfur amino acid metabolism, cystathionine β-synthase activity, and redox biology using isotope dilution techniques.
• Nutritional and Biochemical Research: Employed in studies investigating vitamin B12, B6, and folate deficiency, and their impact on homocysteine/homocystine cycles.
• Quality Control & Method Validation: Essential for developing, validating, and ensuring the compliance of analytical methods in GLP/GMP environments.

Basic Information

Product Name	L-Homocystine-D8
CAS No.	182755-41-5
Molecular Formula	C8D8H8N2O4S2
Molecular Weight	284.38 g/mol
Synonyms	(2R,2'R)-3,3'-(Dithiodi-2,1-ethanediyl)bis(2-aminopropanoic acid)-D8; L-Homocystine (d8); Homocystine-d8; (S,S)-Homocystine-d8; 4,4'-Dithiobis(2-aminobutanoic acid)-D8; Deuterated L-Homocystine; Perdeuterated L-Homocystine; Isotopically Labeled Homocystine
EINECS	Contact for details

Quality Control

Our L-Homocystine-D8 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic purity (by MS), and other critical parameters. We adhere to industry best practices to support research and development in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.