Description

4-Pivalamidophenylboronic Acid is a high-purity, functionalized boronic acid derivative designed for advanced synthetic chemistry. This compound is a critical building block in modern pharmaceutical research and development, particularly for the synthesis of complex molecules via Suzuki-Miyaura cross-coupling reactions. It is essential for medicinal chemists and process development scientists working in pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality intermediates for constructing biaryl and heterobiaryl scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a versatile boronic acid partner for palladium-catalyzed carbon-carbon bond formation, enabling the construction of complex molecular architectures.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening and library synthesis for lead optimization and structure-activity relationship (SAR) studies.
• Agrochemical Synthesis: Employed in the development of novel herbicides, fungicides, and insecticides that require specific aryl-aryl linkages.
• Material Science Research: A building block for creating organic electronic materials, ligands for catalysts, and functional polymers.
• Contract Research & Manufacturing (CRMO): Supplied to organizations specializing in custom synthesis and scale-up of fine chemicals.

Basic Information

Product Name	4-Pivalamidophenylboronic Acid
CAS No.	182344-22-5
Molecular Formula	C11H16BNO3
Molecular Weight	221.06 g/mol
Synonyms	4-(Pivalamido)phenylboronic Acid; 4-(2,2-Dimethylpropanamido)phenylboronic Acid; 4-Pivaloylaminophenylboronic Acid; 4-(Pivaloylamino)benzeneboronic Acid; 4-(Tert-butylcarboxamido)phenylboronic Acid; B-[4-[(2,2-Dimethyl-1-oxopropyl)amino]phenyl]boronic Acid; Pivalic acid (4-boronophenyl)amide
EINECS	Contact for details

Quality Control

Our 4-Pivalamidophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.