Description

4-Bromo-1-Nitro-Isoquinoline is a versatile and highly functionalized heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic positioning of reactive bromo and nitro substituents on the isoquinoline scaffold, enabling precise molecular construction. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and complex chemical intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting neurological disorders and oncology.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides due to its bioactive heterocyclic structure.
• Material Science: Serves as a building block for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl and conjugated systems.
• Nitro Group Reduction: The nitro group can be selectively reduced to an amine, providing a versatile handle for amide bond formation or further functionalization.
• Chemical Biology: Utilized as a scaffold or probe in medicinal chemistry for structure-activity relationship (SAR) studies and target identification.

Basic Information

Product Name	4-Bromo-1-Nitro-Isoquinoline
CAS No.	182184-81-2
Molecular Formula	C9H5BrN2O2
Molecular Weight	253.06 g/mol
Synonyms	4-Bromo-1-nitroisoquinoline; 1-Nitro-4-bromoisoquinoline; Isoquinoline, 4-bromo-1-nitro-; 4-Bromoisoquinoline-1-nitrile N-oxide (related); 4-Bromo-1-nitro-isoquinoline; 182184-81-2; 4-Br-1-NO2-IQ
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-Nitro-Isoquinoline is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and GC/MS for solvent residue analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications. Our commitment is to deliver high-purity, batch-to-batch consistent material to support your critical synthetic pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.