Description

(-)-Tramadol is the pharmacologically active enantiomer of the synthetic opioid analgesic, Tramadol. This high-purity chiral intermediate is critical for the development and production of advanced pharmaceutical formulations targeting specific receptor activity. It is essential for pharmaceutical manufacturers and research institutions focused on enantiomerically pure active pharmaceutical ingredients (APIs) and neuropharmacology studies. Our supply ensures consistent quality and reliability for critical synthesis and development workflows.

Application

• Primary chiral building block for the synthesis of enantiomerically pure Tramadol hydrochloride API.
• Reference standard for analytical method development and quality control in pharmaceutical manufacturing.
• Key intermediate in research focused on the stereoselective pharmacology of opioid analgesics.
• Starting material for the development of novel analgesic compounds and drug delivery systems.
• Used in biochemical research to study mu-opioid receptor binding and signal transduction pathways.
• Critical for impurity profiling and stability studies of Tramadol-based pharmaceutical products.

Basic Information

Product Name	(-)-Tramadol
CAS No.	181289-59-8
Molecular Formula	C16H25NO2
Molecular Weight	263.38 g/mol
Synonyms	(-)-(1R,2R)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol; (1R,2R)-Tramadol; Levotramadol; (1R,2R)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol; Tramadol Enantiomer; (R,R)-Tramadol
EINECS	Contact for details

Quality Control

Our (-)-Tramadol is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D and intermediate use. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and enantiomeric excess. We adhere to cGMP principles where applicable to support our global clientele in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to protect the product from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.