Description

(+)-Tramadol CAS NO 181289-58-7 is the pure enantiomer of the centrally acting analgesic Tramadol, offering a distinct pharmacological profile for advanced research and development. This high-purity chiral intermediate is critical for studying stereoselective metabolism, receptor binding, and developing novel enantiopure pharmaceutical formulations. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard producers, and advanced chemical synthesis units focused on neuropharmacology and pain management research.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity calibrant for analytical methods (HPLC, GC) in quality control and pharmacokinetic studies.
• Chiral Intermediate Synthesis: Used in the research and development of enantiomerically pure drug candidates targeting opioid receptors.
• Metabolite Studies: Essential for investigating the stereoselective metabolism and pharmacokinetics of tramadol in preclinical and clinical research.
• Analytical Method Development: Employed to develop and validate stereospecific assays for the quantification of tramadol enantiomers in various matrices.
• Pharmacological Research: Used in vitro and in vivo studies to elucidate the specific contributions of the (+)-enantiomer to analgesia and side-effect profiles.
• Impurity Profiling: Acts as a critical marker for identifying and quantifying enantiomeric impurities in racemic tramadol API and finished dosage forms.

Basic Information

Product Name	(+)-Tramadol
CAS No.	181289-58-7
Molecular Formula	C16H25NO2
Molecular Weight	263.38 g/mol
Synonyms	(1R,2R)-Tramadol; (+)-(1R,2R)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol; (1R,2R)-Tramadol Hydrochloride (salt form); Tramadol enantiomer (+); Dextro-Tramadol; (R,R)-Tramadol; UNII-39J1LGJ30J; (1R,2R)-rel-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol
EINECS	Contact for details

Quality Control

Our (+)-Tramadol is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets stringent specifications for research and development purposes. A Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and related substances is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Single Maximum Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.