Description

(R)-n-Glycidylphthalimide CAS NO 181140-34-1 is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic utility. Its value lies in its enantiomerically pure glycidyl moiety, which serves as a versatile precursor for introducing functionalized three-carbon units with defined stereochemistry into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and other specialty chemicals requiring precise stereocontrol.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure β-blockers, antiviral agents, and other therapeutic compounds.
• Asymmetric Synthesis: Used in nucleophilic ring-opening reactions to construct complex molecules with defined stereocenters for drug discovery and development.
• Agrochemical Research: Serves as a building block for creating chiral active ingredients in herbicides, fungicides, and insecticides.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for asymmetric catalysis.
• Polymer Modification: Can be used to introduce reactive epoxy and phthalimide functionalities into polymer backbones for specialty materials.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	(R)-n-Glycidylphthalimide
CAS No.	181140-34-1
Molecular Formula	C11H9NO3
Molecular Weight	203.19 g/mol
Synonyms	(R)-Glycidyl Phthalimide; (R)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione; (R)-1,2-Epoxy-3-phthalimidopropane; (R)-N-(Oxiran-2-ylmethyl)phthalimide; (R)-EPH; (R)-N-Glycidylphthalimide; (2R)-2-[(1,3-Dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]oxirane; (R)-N-(2,3-Epoxypropyl)phthalimide
EINECS	Contact for details

Quality Control

Our (R)-n-Glycidylphthalimide is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, NMR for structural confirmation, and standard purity assays. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to prevent moisture absorption and maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	97 - 102 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.