Description

1,2-Dipalmitoyl-D62-Sn-Glycero-3-Phosphocholine-1,1,2,2-D4-N,N,n-Trimethyl-D 9 is a highly deuterated and isotopically labeled phospholipid, specifically designed for advanced research applications. This compound is critical for providing unmatched molecular specificity and signal clarity in sophisticated analytical techniques. It is primarily utilized by research scientists and product developers in the fields of lipidomics, membrane biophysics, and pharmaceutical development, where precise isotopic labeling is essential for mechanistic studies and tracer analysis.

Application

• Biophysical Research: As a deuterated component in model membrane systems (e.g., vesicles, liposomes) for neutron scattering and NMR spectroscopy studies to investigate membrane structure and dynamics.
• Metabolic Tracing: Serving as a stable isotope-labeled internal standard in quantitative lipidomics and mass spectrometry to accurately profile phosphatidylcholine species and metabolic fluxes.
• Pharmaceutical Development: Use in the research and development of lipid-based drug delivery systems, such as liposomal formulations, where isotopic labeling aids in tracking and distribution studies.
• Analytical Reference Standard: Acting as a high-purity certified reference material (CRM) for the calibration of analytical instruments and validation of methods in regulatory and quality control environments.
• Structural Biology: Facilitating advanced structural studies of membrane proteins and lipid-protein interactions using techniques like solid-state NMR.

Basic Information

Product Name	1,2-Dipalmitoyl-D62-Sn-Glycero-3-Phosphocholine-1,1,2,2-D4-N,N,n-Trimethyl-D 9
CAS No.	181041-62-3
Molecular Formula	C42D66NO8P
Molecular Weight	~790.3 g/mol (deuterated form)
Synonyms	DPPC-d62; 1,2-Dihexadecanoyl-D62-sn-glycero-3-phosphocholine-d13; Deuterated DPPC; DPPC (palmitoyl-d31, choline-methyl-d9); 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine (deuterated); Phosphatidylcholine, 1,2-dipalmitoyl-D62; Lipoid DPPC-d62; Avanti Polar Lipids # 860345
EINECS	Contact for details

Quality Control

Our deuterated phospholipids are manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (e.g., D-atom %), chemical purity by NMR and HPLC, and lipid profile. We adhere to cGMP principles where applicable to support preclinical and development work. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. This product is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Conforms to structure
Isotopic Purity (D-atom %)	≥ 98% (by MS/NMR)
Chemical Purity (HPLC)	≥ 95%
Assay (HPLC)	≥ 95% (of main component)
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.