Description

(2S)-2-(1-Oxo-2,3-Dihydro-1H-Isoindol-2-Yl)Propanoic Acid is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. Its value lies in its role as a key building block for the development of novel active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. This compound is essential for research and manufacturing chemists in the pharmaceutical and fine chemical industries who require a reliable source of enantiomerically pure intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of complex drug molecules, particularly for neurological and psychiatric applications.
• API Synthesis: Used in the production route of Active Pharmaceutical Ingredients (APIs) that incorporate the isoindolinone pharmacophore.
• Asymmetric Synthesis: Serves as a starting material or intermediate in asymmetric catalytic processes to create enantiomerically pure compounds.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and the design of new chemical entities in drug discovery programs.
• Process Chemistry Development: Used for scaling up and optimizing synthetic routes in pilot plants and commercial manufacturing.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	(2S)-2-(1-Oxo-2,3-Dihydro-1H-Isoindol-2-Yl)Propanoic Acid
CAS No.	180923-78-8
Molecular Formula	C11H11NO3
Molecular Weight	205.21 g/mol
Synonyms	(S)-2-(1-Oxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid; (S)-2-(1-Oxoisoindolin-2-yl)propanoic Acid; (S)-2-(1-Oxo-2,3-dihydro-1H-isoindol-2-yl)propanoic acid; (2S)-2-(1-Oxo-1,3-dihydro-2H-isoindol-2-yl)propanoic acid; (S)-2-(1-Oxo-2,3-dihydro-1H-isoindol-2-yl)propionic acid; (S)-2-(1-Oxoisoindolin-2-yl)propionic Acid; (S)-2-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our (2S)-2-(1-Oxo-2,3-Dihydro-1H-Isoindol-2-Yl)Propanoic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH Q7 guidelines and can support customer audits and regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Optical Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.