Description

1-Boc-2-Chloro-3-(2-Ethoxycarbonyl-Acetyl)-Indole is a high-purity, advanced pharmaceutical intermediate with a complex indole-based structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) research. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers requiring precise building blocks for complex organic synthesis. Its defined molecular architecture enables the targeted construction of sophisticated drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of investigational new drugs, especially those targeting specific enzyme pathways.
• Oncology Drug Development: Used in the research and production of potential chemotherapeutic agents and kinase inhibitors.
• CNS-Active Compound Synthesis: Serves as a building block for developing novel compounds for neurological and psychiatric disorders.
• Proteolysis Targeting Chimera (PROTAC) Development: Employed in the construction of heterobifunctional molecules for targeted protein degradation.
• Agrochemical Research: Potential intermediate for developing new, high-efficacy crop protection agents.
• Academic & Contract Research: Used in university and CRO laboratories for methodological studies in heterocyclic and medicinal chemistry.

Basic Information

Item	Details
Product Name	1-Boc-2-Chloro-3-(2-Ethoxycarbonyl-Acetyl)-Indole
CAS No.	180922-72-9
Molecular Formula	C18H20ClNO5
Molecular Weight	365.81 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-2-chloro-3-(3-ethoxy-3-oxopropanoyl)-1H-indole; 2-Chloro-3-(3-ethoxy-3-oxopropanoyl)-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 2-chloro-3-(3-ethoxy-3-oxopropanoyl)-1H-indole-1-carboxylate; 1-Boc-2-chloro-3-(3-ethoxy-3-oxopropanoyl)indole; 1-Boc-2-chloro-3-(ethoxyoxalylmethyl)indole; 2-Chloro-1-N-Boc-3-(2-ethoxycarbonylacetyl)indole; 1-Boc-2-chloroindole-3-glyoxylic acid ethyl ester derivative
EINECS	Contact for details

Quality Control

Our 1-Boc-2-Chloro-3-(2-Ethoxycarbonyl-Acetyl)-Indole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.