Description

Octakis-(6-Mercapto-6-Deoxy)-γ-Cyclodextrin is a highly functionalized derivative of γ-cyclodextrin, featuring eight thiol (-SH) groups attached to its macrocyclic scaffold. This unique structure provides exceptional capabilities for forming stable complexes and covalent bonds, making it a powerful tool for molecular encapsulation and surface modification. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications requiring precise molecular recognition and controlled release.

Application

• Drug Delivery Systems: As a multifunctional carrier for enhancing the solubility, stability, and targeted delivery of poorly soluble active pharmaceutical ingredients (APIs).
• Gold Nanoparticle (AuNP) Functionalization: The thiol groups allow for stable self-assembled monolayers on gold surfaces, used in biosensor development and diagnostic assays.
• Chemical Synthesis & Catalysis: Acting as a chiral host or ligand to influence reaction stereoselectivity and create enzyme-mimetic catalytic sites.
• Protein Stabilization & Modification: For protecting proteins from denaturation or for site-specific conjugation via thiol-disulfide exchange reactions.
• Environmental Remediation: Used in the selective capture and removal of heavy metal ions or organic pollutants from aqueous solutions.
• Advanced Material Science: As a building block for creating supramolecular polymers, hydrogels, and functional coatings with tailored properties.

Basic Information

Product Name	Octakis-(6-Mercapto-6-Deoxy)-γ-Cyclodextrin
CAS No.	180839-61-6
Molecular Formula	C96H152O64S8
Molecular Weight	~2801.0 g/mol
Synonyms	γ-Cyclodextrin octakis(6-deoxy-6-mercapto); Per-6-thio-γ-cyclodextrin; Octakis(6-mercapto-6-deoxy)-γ-cyclodextrin; 6A-Thio-γ-cyclodextrin; 6-Mercapto-γ-cyclodextrin; Heptakis(6-deoxy-6-mercapto)-γ-cyclodextrin (common misnomer); γ-cyclodextrin thiol derivative; SH-γ-CD
EINECS	Contact for details

Quality Control

Our Octakis-(6-Mercapto-6-Deoxy)-γ-Cyclodextrin is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with key parameters including assay (by HPLC), thiol content determination, and residual solvent analysis. Specifications can be aligned with research-grade or development-phase material requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation of the thiol groups. The material is moisture-sensitive; keep the container tightly sealed in a cool, dry place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Thiol Content (Titration)	≥ 7.5 mmol/g
Water Content (KF)	≤ 5.0 %
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.