Description

(R)-1-Acetyl-5-[2-(Phenylsulfonyl)Ethyenyl]-3-(n-Methylpyrrolidin-2-Ylmethyl)-1H-Indole is a sophisticated chiral indole derivative, characterized by its acetyl, phenylsulfonyl, and N-methylpyrrolidinylmethyl substituents, which confer unique reactivity and binding properties. This compound is a high-value pharmaceutical intermediate and a critical building block in modern organic synthesis, enabling the construction of complex molecules with precise stereochemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new chemical entities (NCEs), particularly for central nervous system (CNS) targets and other therapeutic areas requiring advanced heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and high-throughput screening libraries.
• Asymmetric Synthesis: Serves as a versatile building block for constructing complex, enantiomerically pure molecules in academic and industrial R&D.
• Chemical Biology Probes: Utilized in the development of molecular probes to study enzyme function and receptor-ligand interactions.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis projects requiring advanced indole chemistry.

Basic Information

Product Name	(R)-1-Acetyl-5-[2-(Phenylsulfonyl)Ethyenyl]-3-(n-Methylpyrrolidin-2-Ylmethyl)-1H-Indole
CAS No.	180637-88-1
Molecular Formula	C26H28N2O3S
Molecular Weight	448.58 g/mol
Synonyms	(R)-1-Acetyl-5-[2-(phenylsulfonyl)ethenyl]-3-[(2R)-1-methylpyrrolidin-2-yl]methyl-1H-indole; (R)-1-Acetyl-5-(2-(phenylsulfonyl)vinyl)-3-((1-methylpyrrolidin-2-yl)methyl)-1H-indole; 1H-Indole, 1-acetyl-5-[2-(phenylsulfonyl)ethenyl]-3-[(2R)-1-methyl-2-pyrrolidinyl]methyl]-, (R)-; 180637-88-1; (R)-enantiomer of a chiral indole sulfone; N-Methylpyrrolidine-substituted indole derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high chemical purity. Each lot is subjected to comprehensive analytical characterization, including chiral HPLC to confirm enantiomeric excess (ee) and NMR for structural verification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, identity, and impurity profiles. We support development and commercial projects with specifications that can meet GMP guidelines for pharmaceutical starting materials upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be sensitive to prolonged exposure to moisture and air; for long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.