Description

4-(Methoxy-D3)-Aniline is a deuterated aromatic amine compound, specifically a trideuterated derivative of 4-methoxyaniline (p-anisidine). This product is a high-value stable isotope-labeled building block, essential for creating internal standards and labeled tracers used in advanced analytical techniques. It is primarily required by research institutions and pharmaceutical companies engaged in drug metabolism and pharmacokinetics (DMPK) studies, proteomics, and the development of quantitative analytical methods such as LC-MS/MS.

Application

• Internal Standard for Mass Spectrometry: Serves as a critical, non-interfering internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and LC-MS/MS for the accurate quantification of its non-deuterated counterpart and related metabolites.
• Pharmaceutical Research & DMPK Studies: Used as a labeled precursor or metabolite analog in drug discovery and development to study absorption, distribution, metabolism, and excretion (ADME) pathways.
• Metabolomics and Proteomics: Employed in stable isotope labeling strategies for the relative and absolute quantification of small molecules and peptides in complex biological samples.
• Synthetic Intermediate: Acts as a specialized building block for the synthesis of more complex deuterated compounds, including pharmaceuticals, agrochemicals, and materials science products.
• NMR Spectroscopy: Useful as a probe in Nuclear Magnetic Resonance (NMR) spectroscopy due to the distinct properties of deuterium atoms.

Basic Information

Product Name	4-(Methoxy-D3)-Aniline
CAS No.	180626-23-7
Molecular Formula	C7H7D3NO
Molecular Weight	125.18 g/mol
Synonyms	p-Anisidine-d3; 4-Methoxyaniline-d3; 4-Aminoanisole-d3; 4-(Trideuteriomethoxy)aniline; 1-Amino-4-(trideuteriomethoxy)benzene; Deuteron-p-Anisidine; CD3O-C6H4-NH2
EINECS	Contact for details

Quality Control

Every batch of 4-(Methoxy-D3)-Aniline is produced and analyzed under strict quality management protocols to ensure the highest isotopic purity and chemical purity. Our products undergo rigorous quality testing, including NMR, HPLC, and MS analysis, to ensure compliance with research and development standards. Certificates of Analysis (COA) detailing isotopic enrichment (D%, atom %), chemical purity, and analytical methods are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, open flames, and strong oxidizing agents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to light yellow crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%, NMR/MS)	≥ 98.0 atom % D
Chemical Purity (NMR/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.