Description

Ethyl (S)-1-Phenyl-1,2,3,4-Tetrahydro-2-Isoquinolinecarboxylate is a high-purity chiral intermediate of significant importance in modern synthetic organic chemistry. Its value lies in its role as a key building block for the enantioselective synthesis of complex bioactive molecules, particularly in pharmaceutical research and development. This compound is essential for chemists and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require a reliable source of stereochemically defined intermediates to accelerate drug discovery and process development.

Application

This chiral intermediate serves as a versatile precursor in the synthesis of a wide range of biologically active compounds. Its primary applications include:

• Pharmaceutical Intermediate: A critical building block for the synthesis of potential drug candidates, particularly those targeting neurological and cardiovascular systems.
• Asymmetric Synthesis: Used in the construction of complex molecules where the (S)-configuration is required for biological activity, leveraging its defined stereocenter.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to develop novel therapeutic agents.
• Catalyst and Ligand Development: Serves as a precursor for novel chiral catalysts or ligands used in enantioselective transformations.
• Fine Chemical Production: Used in the multi-step synthesis of high-value specialty chemicals and advanced materials.
• Reference Standard: Acts as a pure analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Ethyl (S)-1-Phenyl-1,2,3,4-Tetrahydro-2-Isoquinolinecarboxylate
CAS No.	180468-42-2
Molecular Formula	C18H19NO2
Molecular Weight	281.35 g/mol
Synonyms	(S)-Ethyl 1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; (S)-1-Phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylic Acid Ethyl Ester; Ethyl (S)-1-phenyl-3,4-dihydro-2(1H)-isoquinolinecarboxylate; (S)-ETIQ; (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid ethyl ester; 180468-42-2; (S)-1-Phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylate ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl (S)-1-Phenyl-1,2,3,4-Tetrahydro-2-Isoquinolinecarboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high chemical and chiral purity, meeting the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.