Description

(1R)-3,4-Dihydro-1-Phenyl-2(1H)-Isoquinolinecarboxylic Acid Ethyl Ester is a chiral, non-racemic organic compound belonging to the isoquinoline class, serving as a sophisticated building block in advanced chemical synthesis. Its value lies in its well-defined stereochemistry, which is critical for producing enantiomerically pure intermediates with high biological or catalytic relevance. This product is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly for applications in asymmetric synthesis and the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets and enzyme inhibitors.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or building block in stereoselective reactions to construct complex molecular architectures.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic agents.
• Catalyst Ligand Development: Serves as a precursor for synthesizing novel chiral ligands used in homogeneous catalysis.
• Fine Chemical Production: Used in the multi-step synthesis of specialty chemicals requiring high enantiomeric purity.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and process chemistry.

Basic Information

Product Name	(1R)-3,4-Dihydro-1-Phenyl-2(1H)-Isoquinolinecarboxylic Acid Ethyl Ester
CAS No.	180468-41-1
Molecular Formula	C18H17NO2
Molecular Weight	279.33 g/mol
Synonyms	(R)-Ethyl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate; (1R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid ethyl ester; Ethyl (1R)-1-phenyl-3,4-dihydro-2(1H)-isoquinolinecarboxylate; (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic Acid Ethyl Ester; (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate ethyl ester; (R)-ETIQ; (R)-1-Phenyl-1,2,3,4-tetrahydro-2-isoquinolinecarboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our (1R)-3,4-Dihydro-1-Phenyl-2(1H)-Isoquinolinecarboxylic Acid Ethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and precise enantiomeric excess (e.e.), critical for sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be sensitive to moisture and prolonged exposure to air; therefore, handling under an inert atmosphere is recommended for long-term storage of opened containers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.