Description

Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-(hydroxymethyl)-, methyl ester (9Ci) is a high-value, synthetically challenging bicyclic building block prized for its unique three-dimensional structure and functional group versatility. This compound is critical for medicinal chemistry and advanced materials research, enabling the synthesis of novel molecules with improved physicochemical properties. It is primarily sought by pharmaceutical R&D teams and specialty chemical manufacturers for applications in drug discovery, agrochemicals, and polymer science.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of new active pharmaceutical ingredients (APIs), particularly for creating bioisosteres and enhancing metabolic stability.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where its rigid core can improve target binding and environmental persistence.
• Advanced Material Precursor: Acts as a monomer or cross-linking agent for developing specialty polymers with unique thermal and mechanical properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalysis and asymmetric synthesis.
• Chemical Biology Probe Synthesis: Utilized to build molecular tools for studying biological pathways and protein function.
• Academic and Industrial R&D: A valuable reagent for exploratory synthetic chemistry and methodology development in research laboratories.

Basic Information

Product Name	Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-(hydroxymethyl)-, methyl ester (9Ci)
CAS No.	180464-87-3
Molecular Formula	C8H12O3
Molecular Weight	156.18 g/mol
Synonyms	Methyl 3-(hydroxymethyl)bicyclo[1.1.1]pentane-1-carboxylate; 3-(Hydroxymethyl)bicyclo[1.1.1]pentane-1-carboxylic Acid Methyl Ester; Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-(hydroxymethyl)-, methyl ester; 1-(Methoxycarbonyl)bicyclo[1.1.1]pentane-3-methanol; BCP Methyl Ester Derivative
EINECS	Contact for details

Quality Control

Our Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-(hydroxymethyl)-, methyl ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up applications. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.