Description

(1R)-Phenyl-1,2,3,4-Tetrahydroisoquinoline is a chiral tetrahydroisoquinoline derivative of significant interest in advanced organic synthesis. This compound serves as a critical pharmacophore and chiral building block for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, asymmetric synthesis, and process development for therapeutic agents targeting the central nervous system and other disease areas.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential drug candidates, particularly those with neurological activity.
• Asymmetric Catalysis Research: Used as a ligand or a substrate in the development and study of new asymmetric catalytic reactions.
• Medicinal Chemistry & SAR Studies: Employed as a core scaffold for structure-activity relationship (SAR) explorations to optimize biological activity and selectivity.
• Process Chemistry & Route Scouting: Serves as a critical intermediate during the scale-up and optimization of synthetic routes for complex molecules.
• Academic & Industrial R&D: Utilized in research laboratories for the discovery of new chemical entities and novel synthetic methodologies.
• Fine Chemical Synthesis: Acts as a building block for the preparation of specialized, high-value agrochemicals or functional materials.

Basic Information

Product Name	(1R)-Phenyl-1,2,3,4-Tetrahydroisoquinoline
CAS No.	180272-45-1
Molecular Formula	C₁₅H₁₅N
Molecular Weight	209.29 g/mol
Synonyms	(R)-Phenyl-1,2,3,4-tetrahydroisoquinoline; (1R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline; (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline; (R)-PTIQ; (R)-1-Phenyl-THIQ; Tetrahydroisoquinoline, 1-phenyl-, (1R)-; (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our (1R)-Phenyl-1,2,3,4-Tetrahydroisoquinoline is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and enantiomeric purity suitable for demanding research and development applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and degradation. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.