Description

(R)-3-Methyl-1,2,3,4-tetrahydroisoquinoline is a chiral, non-racemic organic compound belonging to the tetrahydroisoquinoline class, a privileged scaffold in medicinal chemistry. This enantiomerically pure building block is critical for the synthesis of complex molecules where stereochemistry dictates biological activity and pharmacological profile. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targets and asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential drug candidates, especially those targeting neurological receptors.
• Asymmetric Catalysis: Used as a ligand or a chiral auxiliary in enantioselective synthesis to induce stereocontrol in chemical reactions.
• Medicinal Chemistry Research: Serves as a core scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Alkaloid Synthesis: An important building block for the total synthesis of complex natural products and alkaloids containing the tetrahydroisoquinoline moiety.
• Chemical Biology Probes: Used in the development of molecular probes to study enzyme mechanisms and biological pathways.

Basic Information

Product Name	(R)-3-Methyl-1,2,3,4-tetrahydroisoquinoline
CAS No.	179893-97-1
Molecular Formula	C₁₀H₁₃N
Molecular Weight	147.22 g/mol
Synonyms	(R)-3-Methyl-1,2,3,4-tetrahydroisoquinoline; (R)-3-Methyl-THIQ; (R)-3-Methyl-1,2,3,4-tetrahydro-isoquinoline; (3R)-3-Methyl-1,2,3,4-tetrahydroisoquinoline; (R)-3-Methyl-3,4-dihydro-1H-isoquinoline; (R)-3-Methyl-1,2,3,4-tetrahydroisoquinolin; (R)-3-Methyl-1,2,3,4-THIQ
EINECS	Contact for details

Quality Control

Our (R)-3-Methyl-1,2,3,4-tetrahydroisoquinoline is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (HPLC), enantiomeric excess (Chiral HPLC), and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.