Description

(3Ar,6As)-Hexahydro-1H-Thieno[3,4-C]Pyrrole Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure. This compound is of significant commercial value as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology industries for the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of novel drug candidates, especially in neurological and psychiatric applications.
• API Development: Serves as a core structural motif for constructing complex molecules with potential biological activity in medicinal chemistry programs.
• Asymmetric Synthesis: Used as a chiral auxiliary or precursor in stereoselective synthesis due to its defined (3Ar,6As) configuration.
• Chemical Research: Employed in academic and industrial R&D for exploring new chemical spaces and reaction methodologies involving bridged heterocycles.
• Process Chemistry: Integral to scaling up and optimizing synthetic routes for potential drug substances in pilot plant and manufacturing settings.

Basic Information

Product Name	(3Ar,6As)-Hexahydro-1H-Thieno[3,4-C]Pyrrole Hydrochloride
CAS No.	179339-70-9
Molecular Formula	C7H12ClNS
Molecular Weight	177.69 g/mol
Synonyms	(3aR,6aS)-Octahydro-1H-thieno[3,4-c]pyrrole hydrochloride; (3aR,6aS)-Octahydrothieno[3,4-c]pyrrole hydrochloride; (3aR,6aS)-1,3a,4,6a-Tetrahydro-3H-thieno[3,4-c]pyrrole hydrochloride; (3aR,6aS)-Hexahydro-1H-thieno[3,4-c]pyrrole HCl; Thienopyrrolidine hydrochloride; Bridged thiophene-pyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our (3Ar,6As)-Hexahydro-1H-Thieno[3,4-C]Pyrrole Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, ensuring data integrity for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.