Description

Benzenemethanol, α-Ethynyl-4-Fluoro-, (R)- (9Ci) is a high-value chiral building block characterized by its benzylic alcohol and terminal alkyne functional groups. This compound is critical for the synthesis of complex, optically active molecules, particularly in pharmaceutical research and development. It is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and production of fluorinated drug candidates, including potential kinase inhibitors and central nervous system (CNS) agents.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to introduce the (R)-configured α-ethynyl benzyl alcohol moiety.
• Asymmetric Synthesis: Serves as a versatile building block in catalytic asymmetric transformations, such as Sonogashira couplings and cycloaddition reactions.
• Agrochemical Research: Employed in the development of novel, optically active pesticides and herbicides where specific stereochemistry is required for bioactivity.
• Material Science Precursor: Potential use in synthesizing specialized monomers for advanced polymers with tailored optical or electronic properties.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and protein interactions via click chemistry.

Basic Information

Product Name	Benzenemethanol, α-Ethynyl-4-Fluoro-, (R)- (9Ci)
CAS No.	179249-15-1
Molecular Formula	C9H7FO
Molecular Weight	150.15 g/mol
Synonyms	(R)-α-Ethynyl-4-fluorobenzyl alcohol; (R)-1-(4-Fluorophenyl)-2-propyn-1-ol; (R)-4-Fluoro-α-(ethynyl)benzenemethanol; (R)-4-Fluorobenzyl alcohol, α-ethynyl-; (R)-1-Ethynyl-4-fluorobenzyl alcohol; (R)-FPEA; (R)-FPE-OH; (R)-4-Fluoro-α-ethynylbenzyl alcohol
EINECS	Contact for details

Quality Control

Our Benzenemethanol, α-Ethynyl-4-Fluoro-, (R)- (9Ci) is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity analysis by HPLC, to ensure high enantiomeric excess (ee) and chemical purity. Certificates of Analysis (COA) detailing identity, assay, chiral purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound may be sensitive to moisture and oxidation; consider storage under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.