Description

(1R)-2-Chloro-1-(4-Chlorophenyl)Ethan-1-Ol CAS NO 178460-80-5 is a chiral chlorinated alcohol derivative, serving as a crucial chiral building block and synthetic intermediate in advanced organic synthesis. Its defined stereochemistry and reactive functional groups make it highly valuable for constructing complex molecules with specific three-dimensional architectures. This compound is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and production of enantiomerically pure drugs, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Used in the development of chiral pesticides and herbicides, where the specific stereoisomer can be critical for biological activity and environmental safety.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing chiral ligands used in asymmetric catalysis, such as in hydrogenation or cross-coupling reactions.
• Material Science Research: Employed in the synthesis of advanced polymers and liquid crystals where chirality influences material properties.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, including new asymmetric synthesis routes.

Basic Information

Product Name	(1R)-2-Chloro-1-(4-Chlorophenyl)Ethan-1-Ol
CAS No.	178460-80-5
Molecular Formula	C8H8Cl2O
Molecular Weight	191.05 g/mol
Synonyms	(R)-2-Chloro-1-(4-chlorophenyl)ethanol; (1R)-2-Chloro-1-(4-chlorophenyl)ethanol; (R)-(-)-2-Chloro-1-(4-chlorophenyl)ethanol; (R)-p-Chlorophenylethylene chlorohydrin; (R)-1-(4-Chlorophenyl)-2-chloroethanol; (R)-α-Chloromethyl-4-chlorobenzyl alcohol; (R)-2-Chloro-1-(p-chlorophenyl)ethanol; (R)-C8H8Cl2O
EINECS	Contact for details

Quality Control

Our production of (1R)-2-Chloro-1-(4-Chlorophenyl)Ethan-1-Ol adheres to stringent in-process controls to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is fully characterized using advanced analytical techniques including chiral HPLC, NMR, and GC-MS. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.