Description

Fmoc-7-Hydroxy-(S)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is a high-purity, non-natural amino acid derivative featuring a protected amine (Fmoc) and a phenolic hydroxyl group. This compound is a critical chiral building block for the solid-phase synthesis of complex peptides and peptidomimetics, enabling the introduction of constrained, bioactive tetrahydroisoquinoline scaffolds. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel drug candidates targeting neurological disorders, oncology, and metabolic diseases.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid for the automated synthesis of therapeutic peptides.
• Peptidomimetic Drug Discovery: Serves as a key scaffold to mimic peptide secondary structures and enhance metabolic stability in drug candidates.
• Combinatorial Chemistry Libraries: Used to generate diverse compound libraries for high-throughput screening against biological targets.
• Neurological Research: Building block for peptides targeting opioid receptors and other central nervous system proteins.
• API Intermediate: A chiral intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Bioconjugation: The phenolic -OH group allows for selective chemical modifications and linker attachments.

Basic Information

Product Name	Fmoc-7-Hydroxy-(S)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid
CAS No.	178432-49-0
Molecular Formula	C26H23NO5
Molecular Weight	429.46 g/mol
Synonyms	(S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; Fmoc-7-OH-Tic-OH; Fmoc-7-hydroxy-(S)-Tic-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-7-hydroxy-(S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-7-hydroxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid; Fmoc-7-hydroxy-L-Tic-OH
EINECS	Contact for details

Quality Control

Our Fmoc-7-Hydroxy-(S)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee reproducible results in your sensitive synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); desiccants are recommended for long-term storage. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.