Description

7-Chloro-6-Aza-2-Oxindole is a high-purity, heterocyclic organic compound with the CAS number 178393-20-9, serving as a critical building block in advanced pharmaceutical synthesis. Its unique oxindole core, functionalized with chlorine and nitrogen, makes it an indispensable intermediate for medicinal chemistry research and development. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries to create novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Synthesis: Serves as a precursor for the synthesis of more complex heterocyclic compounds and specialized fine chemicals.
• Biochemical Research: Employed in the study of enzyme inhibition and biological pathway modulation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the scale-up and production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	7-Chloro-6-Aza-2-Oxindole
CAS No.	178393-20-9
Molecular Formula	C7H3ClN2O
Molecular Weight	166.56 g/mol
Synonyms	7-Chloro-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one; 7-Chloro-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-2-one; 7-Chloro-6-azaoxindole; 7-Chloro-6-aza-2-oxindole; 178393-20-9; 7-Chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; 7-Chloro-3H-pyrrolo[2,3-b]pyridin-2-one
EINECS	Contact for details

Quality Control

Our 7-Chloro-6-Aza-2-Oxindole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.