Description

1-Azabicyclo[2.2.1]Heptane-3-Thiol,(1R,3R,4S)-Rel-(9Ci) is a high-purity, stereochemically defined bicyclic thiol building block of significant interest in advanced organic synthesis. This compound matters for its unique structural framework, which serves as a critical chiral scaffold for constructing complex molecules with precise three-dimensional control. Pharmaceutical and agrochemical research organizations need it for the development of novel active ingredients, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and enzyme inhibition.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, particularly in neuroscience and antiviral therapeutic areas.
• Ligand Synthesis: Used in the preparation of specialized ligands for asymmetric catalysis and metal complexation.
• Peptidomimetic Chemistry: Serves as a constrained, bicyclic amino acid analog for designing and synthesizing peptide mimics with enhanced metabolic stability.
• Agrochemical Research: Employed as a building block in the synthesis of new crop protection agents with specific modes of action.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme function and biological pathways due to its reactive thiol group and rigid structure.
• Material Science: Potential monomer or cross-linking agent in the development of specialty polymers with unique properties.

Basic Information

Product Name	1-Azabicyclo[2.2.1]Heptane-3-Thiol,(1R,3R,4S)-Rel-(9Ci)
CAS No.	178389-37-2
Molecular Formula	C6H11NS
Molecular Weight	129.22 g/mol
Synonyms	(1R,3R,4S)-1-Azabicyclo[2.2.1]heptane-3-thiol; rel-(1R,3R,4S)-1-Azabicyclo[2.2.1]heptane-3-thiol; (1R,3R,4S)-1-Azabicyclo[2.2.1]heptane-3-thiol (rel); 1-Azabicyclo[2.2.1]heptane-3-thiol, (1R,3R,4S)-rel-; Bicyclic thiol amine; 3-Mercapto-1-azabicyclo[2.2.1]heptane (stereoisomer); Endo-3-mercapto-1-azabicyclo[2.2.1]heptane (relative configuration)
EINECS	Contact for details

Quality Control

Our 1-Azabicyclo[2.2.1]Heptane-3-Thiol,(1R,3R,4S)-Rel-(9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided to guarantee identity, purity, and stereochemical integrity.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. For long-term storage, keep the container in a freezer at -20°C. Allow the container to reach room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.