Description

7-Fluoro-2,3,4,9-Tetrahydro-1H-β-Carboline is a fluorinated derivative of the tetrahydro-β-carboline (THBC) scaffold, a privileged structure in medicinal chemistry. This compound serves as a critical synthetic intermediate for the development of novel pharmaceuticals and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for central nervous system (CNS) targets, oncology, and anti-infective research.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel drug candidates targeting serotonin and melatonin receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of fluorination on the β-carboline core's potency and metabolic stability.
• Neurological Disorder Research: Serves as a precursor for compounds being investigated for conditions like anxiety, depression, and sleep disorders.
• Oncological Research: Utilized in the synthesis of potential anti-cancer agents due to the known biological activities of β-carboline alkaloids.
• Chemical Biology Probes: Acts as a scaffold for developing fluorescent or affinity probes to study biological pathways.
• Process Chemistry & Scale-up: Supplied for route scouting and optimization during the development phase of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	7-Fluoro-2,3,4,9-Tetrahydro-1H-β-Carboline
CAS No.	177858-80-9
Molecular Formula	C₁₁H₁₁FN₂
Molecular Weight	190.22 g/mol
Synonyms	7-Fluoro-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole; 7-Fluoro-9H-pyrido[3,4-b]indole, 1,2,3,4-tetrahydro-; 7-Fluoro-THBC; 7-F-THβC; 7-Fluoro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole; 7-Fluoro-1,2,3,4-tetrahydro-β-carboline
EINECS	Contact for details

Quality Control

Our 7-Fluoro-2,3,4,9-Tetrahydro-1H-β-Carboline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic). Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.