Description

D-Alanine-3,3,3-D3-n-T-Boc is a deuterium-labeled, Boc-protected derivative of the non-proteinogenic amino acid D-alanine. This isotopically labeled compound is a critical building block in advanced research and development, offering high isotopic purity and chemical stability for precise analytical and synthetic applications. It is primarily utilized by pharmaceutical researchers, agrochemical developers, and academic institutions engaged in metabolic studies, proteomics, and the synthesis of novel labeled compounds.

Application

• Pharmaceutical Research & Development: As a stable isotope-labeled internal standard for the accurate quantification of D-alanine and related metabolites in bioanalytical methods like LC-MS/MS.
• Metabolic Pathway Tracing: Used in deuterium tracing studies to investigate amino acid metabolism, bacterial cell wall biosynthesis, and other biochemical pathways.
• Proteomics and Peptide Synthesis: A key precursor for the incorporation of deuterium labels into synthetic peptides and proteins for structural analysis, mass spectrometry, and NMR spectroscopy studies.
• Agrochemical Development: Employed in the synthesis of labeled analogs of pesticides or herbicides for environmental fate and metabolism studies.
• Medical Diagnostics Research: Potential use in developing novel diagnostic assays and probes targeting bacterial infections or metabolic disorders.
• Chemical Biology: Serves as a tool compound for studying enzyme mechanisms, particularly those involving alanine racemase or D-amino acid metabolism.

Basic Information

Product Name	D-Alanine-3,3,3-D3-n-T-Boc
CAS No.	177614-70-9
Molecular Formula	C8H12D3NO4
Molecular Weight	192.22 g/mol (for C8H12D3NO4)
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-3,3,3-trideuteriopropanoic acid; Boc-D-alanine-3,3,3-d3; tert-Butyloxycarbonyl-D-alanine-3,3,3-d3; (R)-3,3,3-Trideuterio-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid; D-Alanine-3,3,3-d3, N-BOC; N-Boc-D-alanine-3,3,3-d3; BOC-D-Ala-d3-OH; Deuterated Boc-D-alanine
EINECS	Contact for details

Quality Control

Our D-Alanine-3,3,3-D3-n-T-Boc is manufactured under strict quality systems to ensure batch-to-batch consistency and high isotopic purity. Each lot undergoes comprehensive analytical testing, including NMR, HPLC, and mass spectrometry, to confirm chemical identity, isotopic enrichment (D, %), and chemical purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D)	≥ 98 atom % D
Chemical Purity (by NMR)	≥ 97%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.